This SAPHO syndrome case study follows the assessment and investigation of a 49-year-old woman with a longstanding history of left-sided sternoclavicular joint, shoulder girdle, shoulder and cervical spine pain. Her symptoms had persisted for around 20 years and she had seen a number of healthcare professionals without receiving a clear diagnosis. A recent significant flare prompted further assessment. The clinical findings suggested that the sternoclavicular joint, rather th

This non-secretory multiple myeloma case study follows the assessment and investigation of a 72-year-old woman who presented with persistent rib and thoracic spine pain. The case demonstrates the importance of clinical reasoning, objective assessment and being prepared to reconsider an initial diagnosis when a patient's symptoms do not progress as expected. The patient's initial investigations appeared consistent with osteoporosis and a thoracic vertebral compression fracture